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Janet C. Gonder, Richard A. Kishimoto, Michael D. Kastello, Carl E. Pedersen, Edgar W. Larson, Cynomolgus Monkey Model for Experimental Q Fever Infection, The Journal of Infectious Diseases, Volume 139, Issue 2, February 1979, Pages 191–196, https://doi.org/10.1093/infdis/139.2.191
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Abstract
A subhuman primate model was developed for study of the pathogenesis of infection with Coxiella burnetii. Cynomolgus monkeys (Macaca fascicularis) that were exposed to 105 mouse median infectious intraperitoneal doses of C. burnetii in a small-particle aerosol developed clinical signs of illness and pathologic changes characteristic of Q fever infection in humans. All monkeys had radiologic evidence of pneumonia by day 9. Antibodies to C. burnetii were detectable by the indirect fluorescent antibody test by day 7. These data indicate that the cynomolgus monkey is a suitable model for study of the pathogenesis of Qfever infection and may prove valuable in the evaluation of C. burnetii vaccines.