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Grace M. Thorne, W. Edmund Farrar, Superinfection Compatibility of R Factors in Shigella dysenteriae Type 1 from Central America and Salmonella typhi from Mexico, The Journal of Infectious Diseases, Volume 130, Issue 3, September 1974, Pages 284–287, https://doi.org/10.1093/infdis/130.3.284
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Abstract
Tests of superinfection compatibility demonstrate that the R factors from the epidemic strains of Shigella dysenteriae type 1 and Salmonella typhi belong to different compatibility groups. The R factor from S. dysenteriae belongs to group O, with some partial incompatibility with the lex group, whereas the R factor from S. typhi is compatible with R factors from all groups tested. Thus the appearance of similar patterns of multiple antibiotic resistance in two unusual organisms that caused two major epidemics in the same geographic region within a short period was due to two unrelated R factors.