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Bascom F. Anthony, Terry Yamauchi, Jeffrey S. Penso, Ichiro Kamei, S. Stephen Chapman, Classroom Outbreak of Scarlet Fever and Acute Glomerulonephritis Related to Type 2 (M-2, T-2) Group A Streptococcus, The Journal of Infectious Diseases, Volume 129, Issue 3, March 1974, Pages 336–340, https://doi.org/10.1093/infdis/129.3.336
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Abstract
The recognition of acute glomerulonephritis (AGN) in two members of a second-grade class prompted a survey, which identified a third, asymptomatic student in the same class with AGN. Possibly because of prior antibiotic treatment, streptococci were not recovered from patients with AGN or from the families of two of them. A mixture of group A streptococcal serotypes was found in throat cultures of class members and their families, and no recognized nephritogenic Streptococcus was widely prevalent. A scarlet feverlike illness had recently affected this population, including the three children with AGN, and additional scarlet fever was documented during the study. Type 2 (M-2, T-2) was the only group A Streptococcus isolated from seven of 13 children with recent or acute scarlet fever and was also recovered from several siblings of a child with AGN. Although rarely associated in recent surveys with scarlet fever and not clearly associated in previous reports with AGN, type 2 (M-2, T-2) could be related directly to the occurrence of scarlet fever and indirectly to the development of AGN. Streptococcal pyoderma occurred in a few children, but appeared to play no role in AGN.