-
Views
-
Cite
Cite
Scott B. Halstead, Henry Shotwell, Jordi Casals, Studies on the Pathogenesis of Dengue Infection in Monkeys. II. Clinical Laboratory Responses to Heterologous Infection, The Journal of Infectious Diseases, Volume 128, Issue 1, July 1973, Pages 15–22, https://doi.org/10.1093/infdis/128.1.15
- Share Icon Share
Abstract
Laboratory responses to a second inoculation of a dengue virus were studied in 118 rhesus monkeys challenged at intervals of two, six, 12, and 26 weeks. Nine animals received the same virus twice; the others received a heterologous type. A single animal manifested leukocytosis, thrombocytopenia, elevation of prothrombin time, and decrease in complement during an infection due to dengue 2 virus that followed a pimary dengue 4 infection at an interval of three months. A mild thrombocytopenia was significantly correlated with secondary dengue 2 infections. A sharp decrease in total complement was observed early after secondary infection with dengue 2 in six of eight monkeys. In secondary dengue 1 and 4 infections, titers of viremia were depressed, while viremia was not detected after secondary challenge with dengue 3. Peak titers of secondary dengue 2 viremia were 13-fold higher than peak titers in primary dengue 2 infections. The greater production of virus in certain secondary infections due to dengue viruses could be a controlling mechanism in the postulated immunologic injury in dengue shock syndrome in man.