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William J. Holloway, William A. Taylor, Long-Term Oral Carbenicillin Therapy in Complicated Urinary-Tract Infections, The Journal of Infectious Diseases, Volume 127, Issue Supplement_2, May 1973, Pages S143–S147, https://doi.org/10.1093/infdis/127.Supplement_2.S143
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Abstract
The availability of the indanyl ester of carbenicillin provides an oral preparation of this antibiotic for the treatment of selected patients with urinary infections due to susceptible pathogens. This study was undertaken to evaluate this preparation in the long-term management of such patients. Seventeen of the patients were initially infected with strains of Pseudomonas species while the remaining eight patients were infected with other gram-negative pathogens. The underlying pathology in these patients included renal calculi, obstructive uropathy, neurogenic vesicle dysfunction, ileal conduit urinary diversion, and chronic pyelonephritis. Oral carbenicillin was given for three weeks to 18 months in a dose of 0.5 g four times daily. The results of therapy in this group of patients were surprisingly good. In 19 of the 25 patients there was eradication or suppression of bacteriuria. Twenty of the 25 patients experienced clinical improvement.