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Sandra P. Levison, Donald Kaye, Response of Enterococcal Pyelonephritis to Furosemide-induced Diuresis Alone and in Combination with Ampicillin, The Journal of Infectious Diseases, Volume 127, Issue 6, June 1973, Pages 626–631, https://doi.org/10.1093/infdis/127.6.626
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Abstract
The effect of ampicillin in combination with diuresis (produced by injection of furosemide) on renal titers of enterococci after iv inoculation of 109 enterococci into rats was determined. Ampicillin injections with or without diuresis were started early (four days after the inoculation of enterococci) or late (21 days after the inoculation of enterococci), and continued for 14 days. Ampicillin therapy started early in nondiuresing rats significantly reduced renal titers of enterococci in comparison with controls (rats receiving saline injections). When ampicillin therapy was started at 21 days, there was no decrease in renal titers. Furosemide-induced diuresis slightly lowered renal titers when started early but did not lower titers when started late. Furosemide-induced diuresis plus ampicillin reduced renal titers significantly as compared with nondiuresing rats receiving ampicillin, rats receiving furosemide without ampicillin, and controls. These studies show that diuresis resulting from administration of furosemide plus ampicillin starting four or 21 days after iv injection of enterococci reduces renal titers of bacteria more than either ampicillin or diuresis alone.