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W. Eugene Sanders, Ilija Pejovic, Robert Cacciatore, Henry Valdez, Frank P. Dunbar, Activity of Gentamicin against Mycobacteria In Vitro and against Mycobacterium tuberculosis in Mice, The Journal of Infectious Diseases, Volume 124, Issue Supplement_1, December 1971, Pages S33–S36, https://doi.org/10.1093/infdis/124.Supplement_1.S33
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Abstract
Gentamicin was shown to be a highly active inhibitor of growth of clinical isolates of Mycobacterium tuberculosis and other mycobacteria in vitro. Activity was independent of susceptibility or resistance of the microorganisms to commonly used antituberculous agents. At a comparable dosage, gentamicin was weakly tuberculostatic and less efficacious than streptomycin in treatment of mice infected with M. tuberculosis H37Rv. Since gentamicin possesses antituberculous activity, administration of the drug to patients for other purposes may possibly impede recovery of mycobacteria from clinical specimens. Further investigation of the antituberculous activity of gentamicin appears warranted.