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William J. Holloway, William A. Taylor, Gentamicin and Kanamycin in the Treatment of Gram-Negative Sepsis: A Comparative Study, The Journal of Infectious Diseases, Volume 124, Issue Supplement_1, December 1971, Pages S180–S184, https://doi.org/10.1093/infdis/124.Supplement_1.S180
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Abstract
This study was initiated to compare the efficacy of gentamicin and kanamycin, the latter given either alone or with polymyxin, as the primary therapy in patients with suspected gram-negative sepsis. Seventy of 89 patients entered in the study were considered satisfactory for evaluation; 37 were treated with gentamicin and 33 were given kanamycin (plus polymyxin in 14 instances). There were two significant differences in the therapeutic groups. Twenty patients (54%) of the group treated with gentamicin had imminently fatal underlying disease, while nine (27 %) of the group treated with kanamycin were so afflicted. Likewise, decreased renal function was significantly more frequent in patients in the group treated with gentamicin. There was no significant difference in the response to treatment in the two groups, with more than 50% of the patients responding to either antibiotic regimen. As a result of patient selection, most pseudomonas infections were included in the group treated with gentamicin.
