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Wendy Chaka, Robert Heyderman, Innocent Gangaidzo, Valerie Robertson, Peter Maso Mason, University of Zimbabwe Meningitis Group, Jan Verhoef, Andre Verheul, Andy I. M. Hoepelman, Cytokine Profiles in Cerebrospinal Fluid of Human Immunodeficiency Virus—Infected Patients with Cryptococcal Meningitis: No Leukocytosis despite High Interleukin-8 Levels, The Journal of Infectious Diseases, Volume 176, Issue 6, December 1997, Pages 1633–1636, https://doi.org/10.1086/517344
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Abstract
Cytokine levels were studied in the cerebrospinal fluid (CSF) of 16 adults with cryptococcal meningitis (CM). Low levels of tumor necrosis factor (TNF)-α and interferon-γ, high levels of interleukin (IL)-1β, IL-6, and IL-8, and the presence of IL-10 were documented. There were no significant differences in levels of TNF-α and interferon-γ for CM and control patients. Mean CSF levels of IL-1β (139.5 pg/mL), IL-6 (346 pg/mL), IL-8 (1160 pg/mL), and IL-10 (9.27 pg/mL) were significantly (P < .01) elevated in CM patients compared with levels in control patients. Despite the high CSF levels of IL-8, minimal leukocytosis was seen. Significant correlations between cryptococcal antigen titers and IL-10 levels (r = .8, P < .05), protein and cryptococcal antigen titer (r = .9, P < .05), and protein and IL-10 levels (r = .8, P < .05) were found.