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Bruce G. Gellin, Richard N. Greenberg, Richard H. Hart, Joseph S. Bertino, David H. Stein, Maria A. Deloria, Mary Lou Clements-Mann, Immunogenicity of Two Doses of Yeast Recombinant Hepatitis B Vaccine in Healthy Older Adults, The Journal of Infectious Diseases, Volume 175, Issue 6, June 1997, Pages 1494–1497, https://doi.org/10.1086/516485
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Abstract
To determine the immunogenicity of two doses of yeast recombinant hepatitis B virus (HBV) vaccine containing surface (S) protein, an open-label, multicenter trial was conducted in 199 healthy HBV-seronegative adults ⩾40 years old. Volunteers were randomly assigned to 1 of 5 groups to receive a total of three 10-µg doses, at 0, 1, and 6 months, or a total of two doses of 20 µg and 10 µg, 20 µg and 20 µg, 40 µg and 10 µg, or 40 µg and 20 µg at 0 and 6 months. The 40-µg/20-µg regimen elicited the highest rate of seroprotection (96.2%), with a geometric mean titer of antibody against the S protein of 369 mIU/mL, not significantly different from the 536 mIU/mL achieved with three doses. These results suggest that a two-dose regimen can achieve seroprotection similar to that of the three-dose regimen. Whether a shorter interval can be used or a booster dose will be needed later to confer durable immunity are unknown.