The cover. Upper left: Cheetah (Acinonyx jubatus) at Cheetah Conservation Fund, Namibia, Africa. Systemic amyloid A amyloidosis is a major cause of morbidity and mortality among captive cheetahs. Franklin et al. (pp. 115–121) report a novel genotyping assay to screen for alleles of a nucleotide deletion involved in the transcriptional regulation of the protein responsible for the disease. Photo by Ashley Franklin. Lower left: Feral cat (Felis catus), Australia. Using short tandem repeat genomic markers, Spencer et al. (pp. 104–114) analyzed the population structure of feral cats to determine when the domestic cat first arrived in Australia. Photo by Andrew Cooke, courtesy Invasive Animals CRC. Right: Lioness (Panthera leo) and swimming cub at Okavango, Botswana. In their Perspective article (pp 101–103), Moore et al. discuss the evidence that lions in wetland habitats are genetically distinct from those of the surrounding savannah environment. Photo by Andy Moore.