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Naoki Sakane, Toshihide Yoshida, Takaaki Mizutani, Yuuji Nakagaw, Serum Leptin Levels in a Patient with Pheochromocytomah, The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 4, 1 April 1998, Page 1400, https://doi.org/10.1210/jcem.83.4.4734-8
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We read with great interest the report of Masuzaki et al. (1), which showed that serum leptin levels were increased in patients with Cushing’s syndrome. However, serum leptin levels in a patient with pheochromocytoma, another adrenal tumor, were not described.
A 72-yr-old man complaining of episodic headaches, nausea, palpitations, and perspiration was referred to our department in October 1997. Physical examination showed that the patient was agitated and had striking peripheral vasoconstriction. Blood pressure varied between 240/130 and 80/40 mm Hg; the patient did not have orthostatic hypotension. Plasma noradrenaline and adrenaline levels were increased (2.20 ng/mL and 0.86 ng/mL, respectively), although serum cortisol and aldosterone levels were normal. Twenty-four-hour urinary noradrenaline and adrenaline were also increased (882 μg/day and 138 μg/day, respectively). A tentative diagnosis of pheochromocytoma was made. Computed tomography of the abdomen showed a mass measuring approximately 4 cm in diameter in the left adrenal gland. Pathological examination after left-sided adrenalectomy were compatible with pheochromocytoma. After surgery, the patient had no symptoms and was normotensive. Although serum leptin levels were low before surgery, serum leptin levels were increased with diurnal rhythms 1 month after surgery (Table 1).
