Abstract

The binding capacity of thyroxine-binding globulin (TBG) has been measured in 60 members of a kindred. The data strongly suggest X-linked inheritance of the trait for elevated TBG binding capacity. The results of blood grouping tests indicate that the X-linked Xg locus is not closely linked to the locus for increased TBG capacity.

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Author notes

Supported by USPHS Research Grants GM 15253, AM 12192 and AM 09745 and by Training Grant AM 5331-07. This study was conducted in part through the University of Washington Clinical Research Center at King County Harborview Hospital supported by the NIH (Grant FR-133).

1

Present address: Eugene Clinic, Eugene, Oregon.

2

Address reprint requests to Dr. Fialkow at the Department of Medicine, University of Washington, Seattle, Wash. 98105.