Extract

History

A 47-year-old female without a personal or family history of breast cancer presented with bilateral painful, palpable breast masses. She denied breast trauma. She had a history of hypertension, Crohn’s disease, and end-stage renal disease (ESRD) on hemodialysis. No prior diagnoses of diabetes mellitus or coronary artery disease were noted. Laboratory data revealed secondary hyperparathyroidism with elevated parathyroid hormone, hypocalcemia, and hyperphosphatemia. Review of multiple CTs of the abdomen and pelvis and a chest CT from 2008 was not helpful in the diagnosis. Diagnostic mammogram (Figure 1) and targeted US (Figure 2) were performed to further evaluated the bilateral areas of clinical concern.

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Imaging Findings

Bilateral diagnostic mammogram with spot magnification views (Figure 1) revealed fine pleomorphic and linear branching calcifications with associated underlying focal asymmetry. Notable also were bilateral trabecular and skin thickening, more extensive on the left, as well as advanced vascular calcifications for age. Focused bilateral US (Figure 2) revealed irregular, hypoechoic, avascular masses with posterior shadowing.

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