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Sun-Bok Jang, Ae-Ran Kwon, Woo-Sung Son, Sung Jean Park, Bong-Jin Lee, Crystal Structure of Hypothetical Protein HP0062 (O24902_HELPY) from Helicobacter pylori at 1.65 Å Resolution, The Journal of Biochemistry, Volume 146, Issue 4, October 2009, Pages 535–540, https://doi.org/10.1093/jb/mvp098
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Abstract
The HP0062 gene encodes a small acidic protein of 86 amino acids with a theoretical pI of 4.6. The crystal structure of hypothetical protein HP0062 from Helicobacter pylori has been determined at 1.65 Å by molecular-replacement method. The crystallographic asymmetric unit contains dimer, in which HP0062 monomer folds into a helix–hairpin–helix structure. The two protomers are primarily held together by extensive hydrophobic interactions in an antiparallel arrangement, forming a four helix bundle. Aromatic residues located at a or g position in the heptad leucine zipper are not major contributor required for HP0062 dimerization but important for the thermostability of this protein.