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Chaorong Ge, Zeqing Wei, Yan Jiang, Ping Shen, Yunsong Yu, Lanjuan Li, Identification of KPC-2-producing Pseudomonas aeruginosa isolates in China, Journal of Antimicrobial Chemotherapy, Volume 66, Issue 5, May 2011, Pages 1184–1186, https://doi.org/10.1093/jac/dkr060
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Sir,
KPCs have been reported in different parts of the world since the first identification of KPC-positive Klebsiella pneumoniae in the USA.1,2 The increasing emergence and spread of KPCs leaves fewer available therapeutic options due to their broad-spectrum hydrolytic activity and high mobility.2 The KPC-producing bacteria are mostly Enterobacteriaceae, but also rarely Pseudomonas aeruginosa and Acinetobacter spp.2 The first KPC-producing P. aeruginosa isolates were identified in Colombia.3 Although there have been several reports of KPC-2-producing Enterobacteriaceae in China in recent years, this is the first report of KPC-producing P. aeruginosa in China.
In a surveillance study for assessing asymptomatic colonization with carbapenem-resistant organisms in the intensive care unit (ICU) of a 2200-bed teaching hospital (our hospital, i.e. First Affiliated Hospital, College of Medicine, Zhejiang University) in Hangzhou, 291 faecal specimens or rectal swabs were collected from 139 patients on admission and at 5day intervals after hospitalization and cultured using MacConkey agar plates (bioMérieux, France) containing 1 mg/L meropenem. Species identification was performed using the VITEK 2 system (bioMérieux, France). Ambler class A and B β-lactamase genes were detected for carbapenem-resistant organisms by PCR. Three KPC-2-producing P. aeruginosa isolates (P. aeruginosa 1–3) were recovered from three patients (patients 1–3) who occupied adjacent beds.
