Collection
Practical Considerations for Application of Weight of Evidence in Chemical Evaluations
Guest Editor: Pat Guiney
Table of Contents
Kuan-Chun Lee, Patrick D. Guiney, Charles A. Menzie, Scott E. Belanger
Integrated Environmental Assessment and Management, Volume 19, Issue 5, September 2023, Pages 1188-1191, https://doi.org/10.1002/ieam.4803
David W. Moore, Betsy Ruffle, Andrew McQueen, Sagar Thakali, Deborah Edwards
Integrated Environmental Assessment and Management, Volume 19, Issue 5, September 2023, Pages 1192-1206, https://doi.org/10.1002/ieam.4590
Key Points
- There is a general need for increased sharing of primary toxicological data (e.g., worker epidemiological data) and environmental and biomonitoring data to aid in early identification of potential emerging contaminants (ECs).
- The evaluation of hazard and exposure should include a deeper understanding of the likely environmental fate of the substance, including its mobility, transformation or degradation, and environmental partitioning.
- Greater consideration of the broad range of potential exposure and receptors scenarios is needed.
- Frameworks should allow for incorporation of new technologies (new approach methodologies [NAMs]) for rapid, broad-based review, analysis, and organization of data (e.g., machine learning) to optimize identification of potential environmental and public health issues.
- There is a general need for increased sharing of primary toxicological data (e.g., worker epidemiological data) and environmental and biomonitoring data to aid in early identification of potential emerging contaminants (ECs).
- The evaluation of hazard and exposure should include a deeper understanding of the likely environmental fate of the substance, including its mobility, transformation or degradation, and environmental partitioning.
- Greater consideration of the broad range of potential exposure and receptors scenarios is needed.
- Frameworks should allow for incorporation of new technologies (new approach methodologies [NAMs]) for rapid, broad-based review, analysis, and organization of data (e.g., machine learning) to optimize identification of potential environmental and public health issues.
Andrew N. Miglino, Christopher M. Holmes
Integrated Environmental Assessment and Management, Volume 19, Issue 5, September 2023, Pages 1207-1219, https://doi.org/10.1002/ieam.4602
Key Points
- Weight of evidence applied to exposure assessments provides a useful method for conducting a tiered assessment approach.
- A tiered weight of evidence framework allows for a focused approach to assessing the utility of exposure assessment outcomes.
- Exposure assessments can benefit from incorporating a weight of evidence approach to data gathering and decision making.
- Weight of evidence applied to exposure assessments provides a useful method for conducting a tiered assessment approach.
- A tiered weight of evidence framework allows for a focused approach to assessing the utility of exposure assessment outcomes.
- Exposure assessments can benefit from incorporating a weight of evidence approach to data gathering and decision making.
Scott E. Belanger, Adam D. Lillicrap, S. Jannicke Moe, Raoul Wolf, Kristin Connors, Michelle R. Embry
Integrated Environmental Assessment and Management, Volume 19, Issue 5, September 2023, Pages 1220-1234, https://doi.org/10.1002/ieam.4581
Key Points
- A Bayesian Network (BN) model has been developed to assist prediction of acute fish toxicity using animal alternative methods.
- An array of lines of evidence were used as BN model inputs including data from QSARS, fish embryo tests, gill cytotoxicity tests, the threshold approach, and mode of action assignments.
- Data-rich and data-poor scenarios indicate acute fish toxicity predictions improve when more lines of evidence are used.
- Evaluations confirmed that the use of fish embryo test data to replace acute fish toxicity data were justified in that GHS classification or toxicity interval predictions were the same.
- A Bayesian Network (BN) model has been developed to assist prediction of acute fish toxicity using animal alternative methods.
- An array of lines of evidence were used as BN model inputs including data from QSARS, fish embryo tests, gill cytotoxicity tests, the threshold approach, and mode of action assignments.
- Data-rich and data-poor scenarios indicate acute fish toxicity predictions improve when more lines of evidence are used.
- Evaluations confirmed that the use of fish embryo test data to replace acute fish toxicity data were justified in that GHS classification or toxicity interval predictions were the same.
Jon A. Arnot, Liisa Toose, James M. Armitage, Michelle Embry, Alessandro Sangion, Lauren Hughes
Integrated Environmental Assessment and Management, Volume 19, Issue 5, September 2023, Pages 1235-1253, https://doi.org/10.1002/ieam.4583
Key Points
- The Bioaccumulation Assessment Tool (BAT) guides a user through the process of collecting and generating various lines of evidence (LoE) required for assessing the bioaccumulation of neutral and ionizable organic chemicals in aquatic (water-respiring) and air-breathing organisms.
- The BAT includes data evaluation templates (DETs), primarily developed from standardized testing guidance, to critically evaluate the reliability of the bioaccumulation data used in the weight of evidence (WoE) approach.
- Case study applications of the BAT for hexachlorobenzene (HCB) and β-hexachlorocyclohexane (β-HCH) are used to demonstrate its utility.
- The BAT provides a consistent and transparent WoE framework to address uncertainty in bioaccumulation assessment and is envisaged to evolve with scientific and regulatory developments.
- The Bioaccumulation Assessment Tool (BAT) guides a user through the process of collecting and generating various lines of evidence (LoE) required for assessing the bioaccumulation of neutral and ionizable organic chemicals in aquatic (water-respiring) and air-breathing organisms.
- The BAT includes data evaluation templates (DETs), primarily developed from standardized testing guidance, to critically evaluate the reliability of the bioaccumulation data used in the weight of evidence (WoE) approach.
- Case study applications of the BAT for hexachlorobenzene (HCB) and β-hexachlorocyclohexane (β-HCH) are used to demonstrate its utility.
- The BAT provides a consistent and transparent WoE framework to address uncertainty in bioaccumulation assessment and is envisaged to evolve with scientific and regulatory developments.
