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Susanne Gebhard, Ron S. Ronimus, Hugh W. Morgan, Inhibition of phosphofructokinases by copper(II), FEMS Microbiology Letters, Volume 197, Issue 1, April 2001, Pages 105–109, https://doi.org/10.1111/j.1574-6968.2001.tb10590.x
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Abstract
The biochemical inhibition by Cu2+ on eight phylogenetically and biochemically different phosphofructokinases (PFKs) was investigated. The enzymes screened included representatives from thermophilic and mesophilic bacteria, a hyperthermophilic archaeon and a eukaryote, covering all three phosphoryl donor subtypes (ATP, ADP and pyrophosphate). The sensitivities of the enzymes to Cu2+ varied greatly, with the archaeal ADP-PFK being the least and the eukaryote ATP-PFK being the most sensitive. The bacterial ATP- and pyrophosphate-dependent PFKs showed intermediate sensitivity with the exception of the Spirochaeta thermophila enzyme (pyrophosphate-dependent) which was relatively resistant.