A 41-year-old man underwent pulmonary vein isolation using the second-generation cryoballoon. Following selective angiography (Panel A), right pericardiophrenic vein was cannulated with a 3Fr octapolar electrode catheter over a guidewire (0.014 in.) (Panel B). The threshold of obtaining the maximal compound motor action potential (CMAP) amplitude was 3.0 V with 2.0 ms pulse width. The variability of the amplitude during the cryoapplications was <10%. The major limitation of diaphragmatic CMAP monitoring to anticipate right phrenic nerve injury includes the variability (<30%) in the amplitude during the procedure. Pericardiophrenic vein might be an excellent pacing site to obtain highly stable CMAP during the procedure.