https://orcid.org/0000-0001-6058-8983
-
Views
-
Cite
Cite
Ilais Moreno Velásquez, Bruna Gigante, Do low levels of albuminuria predict mortality among young adults without major cardiovascular risk factors?, European Journal of Preventive Cardiology, Volume 31, Issue 17, November 2024, Pages 2056–2057, https://doi.org/10.1093/eurjpc/zwae223
Close - Share Icon Share
Extract
This editorial refers to ‘The relationship between low levels of albuminuria and mortality among adults without major cardiovascular risk factors’, by S.E. Claudel et al., https://doi.org/10.1093/eurjpc/zwae189.
Chronic kidney disease (CKD), largely undetected worldwide, significantly reduces health-related quality of life and imposes substantial costs on health care systems. Chronic kidney disease has emerged as one of the leading causes of mortality in many regions.1 In response, nephrology societies have advocated for the inclusion of kidney disease in the current World Health Organization statement on major non-communicable disease driving premature mortality.2 Persistent albuminuria is a key biomarker for diagnosing CKD stages. The established clinical cut-offs to define a ‘normal to mild’ albumin–creatinine ratio (formerly known as normoalbuminuria) are an albumin excretion rate < 30 mg/24 h, the approximate equivalent of urinary albumin–creatinine ratio (UACR) of <30 mg/g or <3 mg/mmol.3
In a subpopulation with normal to mildly elevated UACR from the NHANES survey, Claudel et al.4 examined the association between UACR with all-cause and cardiovascular mortality. The study population was free of hypertension, pre-diabetes and diabetes, self-reported cardiovascular disease (CVD), and CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m2 or dialysis).4 The authors reported that doubling in the UACR level, still within the range of normal values, was associated to a 36 and 24% higher risk of cardiovascular and all-cause mortality, respectively, independent of several potential confounding factors. Further, they found a linear increase in the mortality risk. The 15-year cumulative incidence of cardiovascular mortality in this apparently healthy young population was 2.1% among participants with UACR ≥ 6.91 mg/g, in comparison with 0.91% among participants with UACR < 4.18 mg/g.
Comments