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The effects of atorvastatin and micronized fenofibrate on endothelial functions in metabolic syndrome patients: comparative study

MD Demir Hakan, MD Ural Dilek, MD Kozdag Guliz, MD Ertas Gokhan, MD Tayfun Sahin, MD Oner Gokhan, MD Ulas Bildirici

Department of Cardiology, Kocaeli, Turkey

Topic: Obesity

Objective: To compare the effects of atorvastatin 10 mg/day and micronized fenofibrate 200 mg/day on traditional and non-traditional risk and endothelial functions in patients with metabolic syndrome.

Materials and Methods: Sixty-five consecutive patients who were free of coronary artery were studied. Patients were randomized to atorvastatin 10 mg/da yor micronized fenofibrate 200 mg/day. At entry and end of the study; blood and urine samples were collected fort he biochemical analyses and brachial artery reactivity and carotis intima-media thicknes were measured using high resolution ultrasonography.

Results: A total of 52 patients completed the study. With both drugs; treatment goals of total cholesterol, LDL cholesterol, HDL cholesterol and non HDL cholesterol was reached similarly. CRP reductions were significant in both groups (p=0.041 vs p=0.003) By fenofibrate; while levels of fibrinogen, uric acid and inslin were significantly declined and HOMA index was reduced (p= 0.003, p>0,001,; p=0.001, p= 0.002 respectively), a significant rise in the homocystein levels was observed (p=0.015). In each groups; significant (p=0,002 for atorvastatin and p=0.022 for fenofibrate) and similar improvements occured on flow-mediated dilation of the brachial artery.

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