Hypothetical randomized trial design and steps to develop an individualized decision-making tool in patients with NSTE-ACS and complex coronary artery disease. CABG, coronary artery bypass grafting; DAPT, dual antiplatelet therapy; FFRCT, fractional flow reserve derived from computed tomography; NSTE-ACS, non-ST elevation acute coronary syndrome; PCI, percutaneous coronary intervention.
Graphical Abstract

Hypothetical randomized trial design and steps to develop an individualized decision-making tool in patients with NSTE-ACS and complex coronary artery disease. CABG, coronary artery bypass grafting; DAPT, dual antiplatelet therapy; FFRCT, fractional flow reserve derived from computed tomography; NSTE-ACS, non-ST elevation acute coronary syndrome; PCI, percutaneous coronary intervention.

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