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Thomas F Lüscher, Unanswered questions in hypertension: prematurity and long-term trajectories, masked and white coat hypertension, European Heart Journal, Volume 41, Issue 16, 21 April 2020, Pages 1527–1530, https://doi.org/10.1093/eurheartj/ehaa275
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The importance of hypertension as a cardiovascular risk factor was recognized decades ago in the Framingham and other cohorts,1 and the benefit of blood pressure lowering was proved by Edward Freis in his seminal trial published in 1977.2 However, while numerous antihypertensive drugs and procedures have been developed, the causes of hypertension are still not fully understood. However, it has been suggested that early events in life may be important. Pregnancy complications,3 preterm birth,4 as well as assisted reproductive technologies5 have all been associated with elevated blood pressure and cardiovascular risk early in life, an issue that Casey Crump and colleagues from the Icahn School of Medicine at Mount Sinai in New York, USA analysed further, using a population-based study of 4 193 069 singleton live births, in their article entitled ‘Risk of hypertension into adulthood in persons born prematurely: a national cohort study’.6