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Background: Thrombocytopenia after transcatheter aortic valve implantation (TAVI) has been recognized. However, cause of thrombocytopenia post TAVI was not clear.

Purpose: The purpose of this study was to investigate the state and change of the blood coagulation and their influence on post TAVI related thrombocytopenia in patients undergoing TAVI with SAPIEN 3 (S3) or Evolut R (ER).

Methods: We enrolled 63 patients (age: 85±5, male:13) undergoing transfemoral TAVI with S3 (n=38) or ER (n=25) valves. Patients with baseline platelet counts less than 100 ×109/L were excluded in this study. Platelet counts were measured before and after TAVI and 1, 2, 3 and 7 days postoperatively. Coagulation parameters as prothrombin activation fragment 1+2 (F1+2) and thrombin-anti-thrombin complex (TAT) were also assessed. Post TAVI related thrombocytopenia was defined as a decline in platelet count of ≥50% at nadir.

Results: Baseline platelet count was not different between S3 (201×109/L; 183–234×109/L range) and ER (196×109/L; 158–219×109/L range).

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