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M G Giustozzi, M C Vedovati, M Verso, S Conti, P Verdecchia, G Bogliari, L Pierpaoli, G Agnelli, C Becattini, P6285
Predictors of major bleeding in patients aged 90 years or over with atrial fibrillation on anticoagulant treatment, European Heart Journal, Volume 39, Issue suppl_1, August 2018, ehy566.P6285, https://doi.org/10.1093/eurheartj/ehy566.P6285 - Share Icon Share
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Background: Decision-making for anticoagulation in atrial fibrillation (AF) needs to balance the risk of ischaemic stroke against the risk of major bleeding. The risk of bleeding remains a major concern of anticoagulant treatment in elderly patients. However, limited evidences are currently available on predictors of major bleeding in AF patients aged 90 years or older.
Purpose: The aim of this study was to investigate for predictors of major bleeding in AF patients aged 90 years or over while on anticoagulant treatment.
Methods: This multicenter cohort study enrolled AF patients aged 90 years or older treated with either vitamin-K antagonists (VKAs) or direct oral anticoagulants. Cox proportional hazard model was used to identify univariate predictors of major bleeding among the following: sex, age, type of anticoagulant, anticoagulation naïve, laboratory exams (haemoglobin and platelet values, Cockroft-Gault clearance), risk of falls, HAS-BLED and CHA2DS2-VASc score and their individual components. Multivariate analyses were constructed from the set of significant (p<0.50) univariable predictors.