Extract

Background: Systemic Lupus Erythematosus (SLE) is a multi-system autoimmune disorder that is commonly associated with dermatologic, musculoskeletal, serologic and hematologic manifestations. Although Pericarditis is the most common cardiac manifestation of SLE, Coronary Artery Disease (CAD) is a significant cause of morbidity and mortality. Patients with Myocardial Infarction (MI) who have SLE fare worse than those without it. However, more recent data on the prognosis of patients with SLE who develop myocardial infarction is lacking.

Purpose: To analyze the prognosis of patients with SLE getting admitted to hospital with a diagnosis of myocardial infarction.

Methods: Adult admissions with a primary diagnosis of myocardial infarction between 1999 and 2014 were extracted from the National Inpatient Sample using the International Classification of Disease (ICD)-9 code 410.9 (N=1,729,178 weighted N=8,499,400). The data obtained was divided into two categories by using ICD-9 code 710.0 for SLE. We performed bivariate analysis using Chi-Square test to determine the in-hospital mortality percentage across various categorical variables and multivariate analysis using Cox Proportional Hazard Regression to control for confounders and determine the hazard of death within 30 days of admission during the hospitalization in patients with and without SLE.

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