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A Z Pietrucha, T Wojcik, J Jedrzejczyk-Spaho, I Bzukala, M Wnuk, B J Pietrucha, P Werynski, E Konduracka, S Chlopicki, J Nessler, P4426
Evaluation of serum level changes of syndecan-1 in response to orthostatic stress during head-up tilt test in patients with vasovagal syncope, European Heart Journal, Volume 39, Issue suppl_1, August 2018, ehy563.P4426, https://doi.org/10.1093/eurheartj/ehy563.P4426 - Share Icon Share
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Syndecans are single transmembrane domain proteins which to act as coreceptors, especially for G protein-coupled receptors. These core proteins carry three to five heparan sulfate and chondroitin sulfate chains, which allow interaction with a large variety of ligands like fibroblast growth factors, vascular endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Syndecan-1 is a marker of high endothelial glycocalyx degradation that may be useful in the evaluation of endothelial function in a plenty of clinical conditions
The aim of our study was evaluation of the Syndecan-1 serum changes during head-up tilt-test in patients with vasovagal syncope (VVS).
Study population: 25pts (11 men, 14 women) aged 18–42 years (median of age: 21yrs) with VVS referred to HUTT. Cardio- and neurological causes of syncope were previously excluded in all studied pts.
Methods: In all pts HUTT was done according to Westminster protocol with sublingual nitroglycerine (NTG) provocation, in case of negative result of passive tilting.