Extract

Syndecans are single transmembrane domain proteins which to act as coreceptors, especially for G protein-coupled receptors. These core proteins carry three to five heparan sulfate and chondroitin sulfate chains, which allow interaction with a large variety of ligands like fibroblast growth factors, vascular endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Syndecan-1 is a marker of high endothelial glycocalyx degradation that may be useful in the evaluation of endothelial function in a plenty of clinical conditions

The aim of our study was evaluation of the Syndecan-1 serum changes during head-up tilt-test in patients with vasovagal syncope (VVS).

Study population: 25pts (11 men, 14 women) aged 18–42 years (median of age: 21yrs) with VVS referred to HUTT. Cardio- and neurological causes of syncope were previously excluded in all studied pts.

Methods: In all pts HUTT was done according to Westminster protocol with sublingual nitroglycerine (NTG) provocation, in case of negative result of passive tilting.

You do not currently have access to this article.