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R. Everett, C.W.L. Chin, J. Kwiencinski, W.J. Jenkins, M.A. Clavel, S. Mirsadree, A. White, S. Semple, S.K. Prasad, P. Pibarot, D.E. Newby, M.R. Dweck, P457
Longitudinal cardiac magnetic resonance assessment in patients with aortic stenosis, European Heart Journal, Volume 38, Issue suppl_1, August 2017, ehx501.P457, https://doi.org/10.1093/eurheartj/ehx501.P457 - Share Icon Share
Extract
Background: Progressive aortic stenosis (AS) is characterised by the development of left ventricular (LV) hypertrophy and myocardial fibrosis. Both diffuse and focal myocardial fibrosis can be assessed using cardiac magnetic resonance (CMR) although longitudinal studies are lacking.
Purpose: To assess the natural history of myocardial fibrosis in patients with AS and remodelling following aortic valve replacement (AVR).
Methods: 63 patients with aortic stenosis were followed up for 2 years with serial CMR and echocardiography. 28 patients (age 63±13, 68% male, 14% mild, 36% moderate, 50% severe AS) did not undergo intervention (natural history cohort). 35 patients (age 67±8, 73% male, all severe AS) underwent AVR within the first year (AVR cohort). Focal myocardial scarring was assessed using late gadolinium enhancement (LGE) and the burden of diffuse myocardial fibrosis was assessed using T1 mapping and the indexed extracellular volume (iECV; LV end-diastolic myocardial volume multiplied by extracellular volume fraction indexed to body surface area). Annualised change was calculated for all measures.