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Piero Ruggenenti, Giuseppe Remuzzi, Worsening kidney function in decompensated heart failure: treat the heart, don't mind the kidney, European Heart Journal, Volume 32, Issue 20, October 2011, Pages 2476–2478, https://doi.org/10.1093/eurheartj/ehr242
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This editorial refers to ‘Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial’†, by J.E.A. Blair et al., on page 2563
In a post-hoc analysis of the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST), Blair and co-workers found that worsening kidney function shortly after hospitalization and in the early post-discharge period independently predicted cardiovascular mortality and re-hospitalizations because of heart failure (HF).1 These findings confirmed previous evidence that worsening kidney function following hospitalization for decompensated HF is a strong independent predictor of long-term adverse outcomes. An intriguing finding of the above study, however, was that worsening kidney function was also associated with a decrease in body weight and circulating levels of the B-type natriuretic peptide (BNP), changes that reflected an amelioration of fluid congestion and that per se were expected to predict improved outcomes in the long term.
