Abstract

The sera of patients with myocarditis and idiopathic dilated cardiomyopathy contain agonistic autoantibodies that bind to the β1-adrenoceptor. These antibodies recognize epitopes on either the first or second extracellular loop of this receptor and exert in cultured neonatal rat heart myocytes a positive chronotropic effect. This effect is eliminated by β1-adrenoceptor blockade as well as by peptides corresponding to the first or second extracellular loop of the human β1adrenoceptor. The antibodies realize their effects mainly via the β -adrenoceptor-adenylate cyclase-protein kinase A cascade.

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