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R. CRANSWICK, G. CARTER, N. WILKES, G. NELSON, Thrombolysis and coronary occlusion: effects upon the non-infarct zone, European Heart Journal, Volume 13, Issue 6, June 1992, Pages 770–775, https://doi.org/10.1093/oxfordjournals.eurheartj.a060254
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Abstract
Regional wall motion was examined by angiography after 3 weeks in 154 patients taking part in the Thrombolysis in Coronary Occlusion (TICO) Trial. Coronary patency rate was greater after administration of recombinant tissue plasminogen activator, (rt-PA 62/77pts 81%) than after a placebo (P 49/77pts 64% P = 0.02), particularly for the left anterior descending artery compared with the right coronary artery (LAD 27/28 96% vs RCA 28/40 70% P=0.006). Left ventricular ejection fraction (LVEF) was preserved after rt-PA (rt-PA 59 ±14% vs P53±15% P = 0.01), predominantly because of more effective non-infarct zone contraction (rt-PA 0.52± 1.16 SD/cord vs P 1.01±1.07 SD/cordP=0.008). Infarct zone scores differed little (rt-PA 2.88 ±0.95 SD/cord vs P 3.16±1.11 SD/cordP=0.09). Left ventricular ejection fraction and non-infarct zone function were best pre⋅erved after rt-PA compared with the placebo, particularly in patients with single vessel disease and in patients in whom the infarct-related artery was the left anterior descending vessel.