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G. Assmann, Genes and dyslipoproteinaemias, European Heart Journal, Volume 11, Issue suppl_H, January 1990, Pages 4–8, https://doi.org/10.1093/eurheartj/11.suppl_H.4
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Abstract
The Prospective Cardiovascular Münster (PROCAM) Study clearly demonstrated that low levels of high density lipoprotein (HDL)-cholesterol are a powerful predictor of subsequent coronary heart disease (CHD) and that both exogenous factors (cigarette smoking, physical inactivity, obesity) and genetic factors (dyslipidaemia, diabetes mellitus) affect serum concentrations of HDL-cholesterol. in case-control studies, the apoprotein (apo) B/apo A-I ratio was found to be more meaningful than the lipoprotein lipid ratio in predicting risk of CHD in a group of young myocardial infarction (MI) survivors. Screening of young (≤45 years) MI survivors did not show an increased prevalence of apo A-I variants compared with controls and newborns, thus apo A-I variants probably do not contribute substantially to low HDL-cholesterol levels and the risk of CHD in the general population. Genetic anomalies causing HDL-cholesterol depletion or apo A-I deficiency probably do not relate to structural anomalies of apo A-I but rather to regulatory anomalies in the production of HDL apolipoproteins or to catabolic or intracellular events that are important in the homeostasis of plasma HDL-cholesterol.
- apolipoproteins
- dyslipidemias
- myocardial infarction
- obesity
- smoking
- high density lipoprotein cholesterol
- lipoproteins
- diabetes mellitus
- cholesterol
- lack of exercise
- homeostasis
- high density lipoproteins
- cardiovascular system
- genes
- newborn
- plasma
- survivors
- apolipoprotein a-i
- apoproteins
- genetic aspects
- lipids
- coronary heart disease
- coronary heart disease risk
- structural anomaly
- gene abnormality