Volume 141, Issue 6, June 2000

Insulin-Glucagon-GI Peptides-Diabetes Mellitus

Introduction to the Diabetes Focus Issue ofEndocrinology

Don McClain

Endocrinology, Volume 141, Issue 6, June 2000, Page 1916, https://doi.org/10.1210/endo.141.6.7600

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Perspective: The Insulin Signaling System—A Common Link in the Pathogenesis of Type 2 Diabetes

Dominic J. Withers and Morris White

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1917–1921, https://doi.org/10.1210/endo.141.6.7584

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Perspective: Hexosamines and Nutrient Sensing

Luciano Rossetti

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1922–1925, https://doi.org/10.1210/endo.141.6.7566

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Perspective: Postnatal Pancreatic β Cell Growth

Susan Bonner-Weir

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1926–1929, https://doi.org/10.1210/endo.141.6.7567

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Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats

Margarzata Szayna and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1936–1941, https://doi.org/10.1210/endo.141.6.7490

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Overexpression of Glutamine:Fructose-6-Phosphate Amidotransferase in Rat-1 Fibroblasts Enhances Glucose-Mediated Glycogen Accumulation via Suppression of Glycogen Phosphorylase Activity

Errol D. Crook and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1962–1970, https://doi.org/10.1210/endo.141.6.7483

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Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells

Gordon C. Yaney and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1989–1998, https://doi.org/10.1210/endo.141.6.7493

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Hexosamines Stimulate Leptin Production in Transgenic Mice

Donald A. McClain and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1999–2002, https://doi.org/10.1210/endo.141.6.7532

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Cytokines Induce Both Necrosis and Apoptosis via a Common Bcl-2-Inhibitable Pathway in Rat Insulin-Producing Cells

Johan Saldeen

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2003–2010, https://doi.org/10.1210/endo.141.6.7523

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Intracellular Signal Systems

Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin-Induced Insulin Receptor Substrate-1 Degradation in 3T3-L1 Adipocytes

Katsuya Egawa and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1930–1935, https://doi.org/10.1210/endo.141.6.7516

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Stat 5B, Activated by Insulin in a Jak-Independent Fashion, Plays a Role in Glucokinase Gene Transcription

Dominique Sawka-Verhelle and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1977–1988, https://doi.org/10.1210/endo.141.6.7496

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Nongenomic Action of Progesterone: Activation of XenopusOocyte Phospholipase C through a Plasma Membrane-Associated Tyrosine Kinase

Thomas Morrison and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2145–2152, https://doi.org/10.1210/endo.141.6.7510

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The Activation of Phospholipase D by Endothelin-1, Angiotensin II, and Platelet-Derived Growth Factor in Vascular Smooth Muscle A10 Cells Is Mediated by Small G Proteins of the ADP-Ribosylation Factor Family

Kuntala Shome and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2200–2208, https://doi.org/10.1210/endo.141.6.7517

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Luteinizing Hormone (LH) Drives Diverse Intracellular Calcium Second Messenger Signals in Isolated Porcine Ovarian Thecal Cells: Preferential Recruitment of Intracellular Ca²⁺ Oscillatory Cells by Higher Concentrations of LH

C. Aguirre and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2220–2228, https://doi.org/10.1210/endo.141.6.7501

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CRH-ACTH-POMC-Adrenal

Agouti-Related Protein-Like Immunoreactivity: Characterization of Release from Hypothalamic Tissue and Presence in Serum

Ji-Yao Li and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1942–1950, https://doi.org/10.1210/endo.141.6.7462

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Adrenomedullin Enhances Cell Proliferation and Deoxyribonucleic Acid Synthesis in Rat Adrenal Zona Glomerulosa: Receptor Subtype Involved and Signaling Mechanism

Paola G. Andreis and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2098–2104, https://doi.org/10.1210/endo.141.6.7508

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Infusion of N-Proopiomelanocortin-(1–77) Increases Adrenal Weight and Messenger Ribonucleic Acid Levels of Cytochrome P₄₅₀ 17α-Hydroxylase in the Sheep Fetus during Late Gestation

J. T. Ross and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2153–2158, https://doi.org/10.1210/endo.141.6.7499

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Nitric Oxide and Carbon Monoxide Have a Stimulatory Role in the Hypothalamic-Pituitary-Adrenal Response to Physico-Emotional Stressors in Rats

C. Kwon Kim and Catherine L. Rivier

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2244–2253, https://doi.org/10.1210/endo.141.6.7500

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Miscellaneous

Blood to Brain Transfer of Leptin in Normal and Interleukin-1β-Treated Male Rats

Seymour Reichlin and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1951–1954, https://doi.org/10.1210/endo.141.6.7459

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Identification of ADAM 31: A Protein Expressed in Leydig Cells and Specialized Epithelia

Limin Liu and Jeffrey W. Smith

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2033–2042, https://doi.org/10.1210/endo.141.6.7497

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Down-Regulation of Thyroid Transcription Factor-1 Gene Expression in Fetal Lung Hypoplasia Is Restored by Glucocorticoids

Alejandro Losada and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2166–2173, https://doi.org/10.1210/endo.141.6.7522

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CCN Proteins Are Distinct from and Should Not Be Considered Members of the Insulin-Like Growth Factor-Binding Protein Superfamily

Gary R. Grotendorst and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2254–2256, https://doi.org/10.1210/endo.141.6.7485

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Receptors

Transcellular Transport of Leptin by the Short Leptin Receptor Isoform ObRa in Madin-Darby Canine Kidney Cells

Stanley M. Hileman and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1955–1961, https://doi.org/10.1210/endo.141.6.7450

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Differential Expression and Regulation of Estrogen Receptors (ERs) in Rat Pituitary and Cell Lines: Estrogen Decreases ERα Protein and Estrogen Responsiveness

Derek A. Schreihofer and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2174–2184, https://doi.org/10.1210/endo.141.6.7505

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Identification of an Estrogen-Mediated Deoxyribonucleic Acid-Binding Independent Transactivation Pathway on the Epidermal Growth Factor Receptor Gene Promoter

Luisa Salvatori and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2266–2274, https://doi.org/10.1210/endo.141.6.7521

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Augmentation of Thyroid Hormone Receptor-Mediated Transcription by Ca²⁺/Calmodulin-Dependent Protein Kinase Type IV

Momoyo Kuno-Murata and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2275–2278, https://doi.org/10.1210/endo.141.6.7612

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Reproduction-Development

The in Vivo and in Vitro Effects of Exogenous Leptin on Ovulation in the Rat

Priya S. Duggal and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 1971–1976, https://doi.org/10.1210/endo.141.6.7509

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Prolactin Induces Apoptosis in the Penultimate Spermatogonial Stage of the Testes in Japanese Red-Bellied Newt (Cynops pyrrhogaster)

Takashi Yazawa and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2027–2032, https://doi.org/10.1210/endo.141.6.7492

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A 278 bp Region Just Upstream of the Human CYP19 (Aromatase) Gene Mediates Ovary-Specific Expression in Transgenic Mice

Margaret M. Hinshelwood and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2050–2053, https://doi.org/10.1210/endo.141.6.7611

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Transforming Growth Factor-β Receptor Types I and II in Cultured Porcine Leydig Cells: Expression and Hormonal Regulation

Isabelle Goddard and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2068–2074, https://doi.org/10.1210/endo.141.6.7498

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Neuroendocrinology

The Relationship between Pulsatile Secretion and Calcium Dynamics in Single, Living Gonadotropin-Releasing Hormone Neurons

Lucía Núñez and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2012–2017, https://doi.org/10.1210/endo.141.6.7491

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Immortalized Luteinizing Hormone-Releasing Hormone Neurons Show a Different Migratory Activity in Vitro

Roberto Maggi and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2105–2112, https://doi.org/10.1210/endo.141.6.7494

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Differential Expression and Regional Distribution of Steroid Receptor Coactivators SRC-1 and SRC-2 in Brain and Pituitary

O. C. Meijer and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2192–2199, https://doi.org/10.1210/endo.141.6.7489

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Annexin 1 (Lipocortin 1) Mediates the Glucocorticoid Inhibition of Cyclic Adenosine 3′,5′-Monophosphate-Stimulated Prolactin Secretion

A. D. Taylor and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2209–2219, https://doi.org/10.1210/endo.141.6.7512

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TRH-TSH-Thyroid

Identification of an Immunodominant Region Recognized by Human Autoantibodies in a Three-Dimensional Model of Thyroid Peroxidase

Paul Hobby and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2018–2026, https://doi.org/10.1210/endo.141.6.7506

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Thyrotropin Modulates Interferon-γ-Mediated Intercellular Adhesion Molecule-1 Gene Expression by Inhibiting Janus Kinase-1 and Signal Transducer and Activator of Transcription-1 Activation in Thyroid Cells

Jongkyeong Chung and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2090–2097, https://doi.org/10.1210/endo.141.6.7507

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Thyroid Hormone Regulation of Phospholamban Phosphorylation in the Rat Heart

Kaie Ojamaa and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2139–2144, https://doi.org/10.1210/endo.141.6.7514

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PTH-Calcitonin-Vitamin D-Bone

Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice

Yoshiyuki Sakai and Marie B. Demay

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2043–2049, https://doi.org/10.1210/endo.141.6.7515

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Knockout of the Murine Prostaglandin EP₂ Receptor Impairs Osteoclastogenesis in Vitro

Xiaodong Li and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2054–2061, https://doi.org/10.1210/endo.141.6.7518

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Evidence for a Functional Association between Phosphatidylinositol 3-Kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1

Andrew Grey and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2129–2138, https://doi.org/10.1210/endo.141.6.7480

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Npt2 Gene Disruption Confers Resistance to the Inhibitory Action of Parathyroid Hormone on Renal Sodium-Phosphate Cotransport

Ningxia Zhao and Harriet S. Tenenhouse

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2159–2165, https://doi.org/10.1210/endo.141.6.7484

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Transforming Growth Factor-β Stimulates Inorganic Phosphate Transport and Expression of the Type III Phosphate Transporter Glvr-1 in Chondrogenic ATDC5 Cells

Gaby Palmer and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2236–2243, https://doi.org/10.1210/endo.141.6.7495

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Growth Factors-Cytokines-Oncogenes

Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 Regulate the Expression of Insulin-Like Growth Factor-Binding Protein-3, -4, and -5 in Large Vessel Endothelial Cells

Gunilla Dahlfors and Hans J. Arnqvist

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2062–2067, https://doi.org/10.1210/endo.141.6.7481

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Mechanisms of Fibroblast Growth Factor-2 Modulation of Vascular Endothelial Growth Factor Expression by Osteoblastic Cells

Pierre B. Saadeh and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2075–2083, https://doi.org/10.1210/endo.141.6.7502

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Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site

Samuel Varghese and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2185–2191, https://doi.org/10.1210/endo.141.6.7504

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Overexpression of Insulin-Like Growth Factor Binding Protein-5 Helps Accelerate Progression to Androgen-Independence in the Human Prostate LNCaP Tumor Model through Activation of Phosphatidylinositol 3′-Kinase Pathway

Hideaki Miyake and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2257–2265, https://doi.org/10.1210/endo.141.6.7520

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GRH-Somatostatin-GH

High Plasma Growth Hormone (GH) Levels Inhibit Expression of GH Secretagogue Receptor Messenger Ribonucleic Acid Levels in the Rat Pituitary

Ralf Nass and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2084–2089, https://doi.org/10.1210/endo.141.6.7503

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Growth Hormone-Releasing Hormone Stimulates Mitogen-Activated Protein Kinase

Celia M. Pombo and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2113–2119, https://doi.org/10.1210/endo.141.6.7513

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Impairment of Cardiac Function and Bioenergetics in Adult Transgenic Mice Overexpressing the Bovine Growth Hormone Gene

Entela Bollano and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2229–2235, https://doi.org/10.1210/endo.141.6.7486

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Cancer

Antagonists of Growth Hormone-Releasing Hormone and Vasoactive Intestinal Peptide Inhibit Tumor Proliferation by Different Mechanisms: Evidence from in Vitro Studies on Human Prostatic and Pancreatic Cancers

Zoltan Rekasi and others

Endocrinology, Volume 141, Issue 6, June 2000, Pages 2120–2128, https://doi.org/10.1210/endo.141.6.7511

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