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Most Cited Articles

Explore European Heart Journal - Quality of Care & Clinical Outcomes (EHJ-QCCO) articles that are making a big impact! The EHJ-QCCO editors invite you to read the top 15 most cited articles published within the past 12 months. This page is automated to reflect current readership, so bookmark this page and check back often to stay up to date with recent changes.

Global burden of ischaemic heart disease from 2022 to 2050: projections of incidence, prevalence, deaths, and disability-adjusted life years
Hujuan Shi and others
European Heart Journal - Quality of Care and Clinical Outcomes, qcae049, https://doi.org/10.1093/ehjqcco/qcae049
Aims Ischaemic heart disease (IHD) has been a significant public health issue worldwide. This study aims to predict the global burden of IHD in a timely and comprehensive manner. Methods and results Incidence, prevalence, deaths, and disability-adjusted life years (DALYs) for IHD from 1990 to 2021 were derived from the ...
Relation of changes in ABC pathway compliance status to clinical outcomes in patients with atrial fibrillation: a report from the COOL-AF registry
Rungroj Krittayaphong and others
European Heart Journal - Quality of Care and Clinical Outcomes, qcae039, https://doi.org/10.1093/ehjqcco/qcae039
Aims The Atrial fibrillation Better Care (ABC) pathway provides a framework for holistic care management of atrial fibrillation (AF) patients. This study aimed to determine the impact of changes in compliance to ABC pathway management on clinical outcomes. Methods and results This is a prospective multicenter AF registry. ...
Estimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study
Katharina Mohr and others
European Heart Journal - Quality of Care and Clinical Outcomes, qcae050, https://doi.org/10.1093/ehjqcco/qcae050
Aims Patients surviving acute pulmonary embolism (PE) necessitate long-term treatment and follow-up. We estimated, the chronic economic impact of PE on the German healthcare system. Methods and results We calculated the direct cost of illness during the first year after discharge for the index PE, analysing data from a ...
The effect of pharmacist-led interventions on the appropriateness and clinical outcomes of anticoagulant therapy: a systematic review and meta-analysis
Belayneh Kefale and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 10, Issue 6, September 2024, Pages 488–506, https://doi.org/10.1093/ehjqcco/qcae045
Aim Although pharmacist-led interventions in anticoagulant (AC) therapy are widely accepted, there is a lack of evidence comparing their effectiveness with usual care in terms of AC therapy appropriateness and clinical outcomes. We aimed to estimate the comparative effectiveness of pharmacist-led interventions on the ...
Global, regional, and national burden of atrial fibrillation/flutter related to metabolic risks over three decades: estimates from the global burden of disease study 2019
Xi Jiang and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 10, Issue 5, August 2024, Pages 391–401, https://doi.org/10.1093/ehjqcco/qcae033
Aims Atrial fibrillation/atrial flutter (AF/AFL) remains a significant public health concern on a global scale, with metabolic risks playing an increasingly prominent role. This study aimed to investigate comprehensive epidemiological data and trends concerning the metabolic risks related-AF/AFL burden based on the data ...
Frequency of misdiagnosis in hypertrophic cardiomyopathy
Søren K Nielsen and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 11, Issue 2, March 2025, Pages 105–112, https://doi.org/10.1093/ehjqcco/qcae031
Background and aims Hypertrophic cardiomyopathy (HCM) is characterized by unexplained left ventricular hypertrophy (LVH) ≥15 mm. The condition is often hereditary, and family screening is recommended to reduce the risk of adverse disease complications and premature death among relatives. Correct diagnosis of index patients ...
Serial cardiopulmonary exercise testing in young patients after one-and-half ventricle repair and Fontan procedure: a comparative study
Marco Vecchiato and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 10, Issue 7, November 2024, Pages 602–611, https://doi.org/10.1093/ehjqcco/qcae041
Aim The Fontan procedure is a palliative surgical treatment for different congenital heart diseases with a univentricular heart, but it has been associated with decreased exercise capacity, cardiovascular morbidity, and premature mortality. The one-and-half ventricle repair (1.5VR) was introduced as an alternative to the ...
Catheter ablation as an adjunctive therapy to ICD implantation in Brugada Syndrome
Ioannis Doundoulakis and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 10, Issue 7, November 2024, Pages 590–601, https://doi.org/10.1093/ehjqcco/qcae040
Background Brugada Syndrome (BrS) is a life-threatening cardiac arrhythmia disorder associated with an increased risk of ventricular arrhythmias (VAs) and sudden cardiac death. Current management primarily relies on implantable cardioverter-defibrillators (ICDs), but patients may experience ICD shocks. Catheter ablation ...
Early goal-directed management after out-of-hospital cardiac arrest: lessons from a certified cardiac arrest centre
Birgit Markus and others
European Heart Journal - Quality of Care and Clinical Outcomes, qcae032, https://doi.org/10.1093/ehjqcco/qcae032
Background Despite continuous advances in post-resuscitation management, the outcome after out-of-hospital cardiac arrest (OHCA) is limited. To improve the outcome, interdisciplinary cardiac arrest centres (CACs) have been established in recent years, but survival remains low, and treatment strategies vary considerably in ...
Coronary revascularization and sex differences in cardiovascular mortality after myocardial infarction in 12 high and middle-income European countries
Edina Cenko and others
European Heart Journal - Quality of Care and Clinical Outcomes, qcae035, https://doi.org/10.1093/ehjqcco/qcae035
Background Existing data on female sex and excess cardiovascular mortality after myocardial infarction (MI) mostly come from high-income countries (HICs). This study aimed to investigate how sex disparities in treatments and outcomes vary across countries with different income levels. Methods Data from the ISACS Archives ...
The Italian Fabry Disease Cardiovascular Registry (IFDCR)
Giuseppe Limongelli and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 10, Issue 6, September 2024, Pages 483–487, https://doi.org/10.1093/ehjqcco/qcae052
Aims The Italian Fabry Disease Cardiovascular Registry (IFDCR) comprises 50 Italian centres with specific expertise in managing cardiovascular manifestations and complications of patients with Fabry disease (FD). The primary aim of the IFDCR is to examine and improve the clinical care and outcomes of patients with FD by ...
Bacteraemia and infective endocarditis following left-sided heart valve surgery
Christine Holgersson and others
European Heart Journal - Quality of Care and Clinical Outcomes, qcae080, https://doi.org/10.1093/ehjqcco/qcae080
Background and aims In patients undergoing heart valve surgery, subsequent bacteraemia and infective endocarditis (IE) are feared events. Data on the incidence and bacterial microbiological etiology following left-sided heart valve surgery are sparse. Methods and results Between 2010 and 2021, all patients undergoing ...
Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography
Apostolos Tsiachristas and others
European Heart Journal - Quality of Care and Clinical Outcomes, qcae085, https://doi.org/10.1093/ehjqcco/qcae085
Aims Coronary computed tomography angiography (CCTA) is a first-line investigation for chest pain in patients with suspected obstructive coronary artery disease (CAD). However, many acute cardiac events occur in the absence of obstructive CAD. We assessed the lifetime cost-effectiveness of integrating a novel artificial ...
Wait-times benchmarks for risk-based prioritization in transcatheter aortic valve implantation: a simulation study
Rafael N Miranda and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 11, Issue 1, January 2025, Pages 10–18, https://doi.org/10.1093/ehjqcco/qcae059
Background Demand for transcatheter aortic valve implantation (TAVI) has increased in the last decade, resulting in prolonged wait-times and undesirable health outcomes in many health systems. Risk-based prioritization and wait-times benchmarks can improve equitable access to patients. Methods and results We used ...
Diagnosis and management of dilated cardiomyopathy: a systematic review of clinical practice guidelines and recommendations
Anna Sorella and others
European Heart Journal - Quality of Care and Clinical Outcomes, Volume 11, Issue 2, March 2025, Pages 206–222, https://doi.org/10.1093/ehjqcco/qcae109
Dilated cardiomyopathy (DCM) is extensively discussed in numerous expert consensus documents and international guidelines, with differing recommendations. To support clinicians in daily practice and decision-making, we conducted a systematic review of key guidelines and recommendations concerning the diagnosis and clinical ...
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