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Clement Karsenty, David Levy, Laurence Iserin, Gilles Soulat, Paradoxical right heart failure due to persistent ductus arteriosus, European Heart Journal - Cardiovascular Imaging, Volume 19, Issue 2, February 2018, Page 240, https://doi.org/10.1093/ehjci/jex253
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A 36-year-old Caucasian male was referred to our unit for subacute and severe heart failure, mainly right heart failure (RHF) with related cachexia. He was known to have patent ductus arteriosus (PDA) since childhood, associated with massive pulmonary regurgitation (PR) sequela of endocarditis, medically treated.
Transthoracic echocardiogram (Panel A) revealed dilated left ventricle and right ventricle with biventricular dysfunction and severe PR. PDA minimal diameter was about 5 mm with exclusive left-to-right shunt (V = 4.5 ms−1). Right atrium pressure was elevated. PR was thought to have a preponderant place in the clinical setting of RHF. Surgical pulmonary valve replacement (PVR) associated to PDA closure was initially viewed as the first therapeutic option. However, clinical presentation and biventricular dysfunction predicted a significant surgical risk.
To better understand this RHF pathophysiology, we performed a 4D flow magnetic resonance imaging (MRI) at 1.5 T (SignaHDxt, GEHC). First, streamlines representation illustrated flow coming from the PDA to the right ventricle through the PR (Panels B and C, see Supplementary data online Video S1). Second, we were able to measure precisely the flows at different levels (Panel D) and found that PR was responsible for right heart volume overload massively exacerbated by the PDA shunt (QP/QS = 4.0). We performed an isolated percutaneous closure of the PDA. Patient’s symptoms improved within 24 h spectacularly. PVR is planned in the second stage, more safely. This case illustrates the help of 4D flow MRI in the understanding of complicated haemodynamic situations, alike congenital heart diseases, and thus in choosing therapeutic options.