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Purpose: The ratio of early diastolic mitral inflow velocity ( E ) to early diastolic tissue Doppler (TDI) annular velocity ( E ′), or E / E ′, is an index of diastolic dysfunction. Pulsed wave (PW) TDI measures peak E ′ while colour TDI measures mean E ′. Previously reported normal PW TDI derived E / E ′ values are therefore not interchangeable with those derived from colour TDI. The aim of this study was to obtain normal values for colour TDI derived E / E ′.

Methods: Seventy-four healthy controls (age range 24–86 years) underwent 2-D colour TDI. E ′ was measured at septal and lateral sites in apical 4-chamber view and E / E ′ was then calculated.

Results: Controls were classified into 5 age groups: <50, 50–59, 60–69, 70–79 and >80 years. Septal annular E ′ (mean±standard deviation) were respectively: 7.15±1.61cm/s, 5.85±0.65, 5.01±1.00, 4.40±0.75, 4.14±1.12 and lateral annular E ′ 9.84±2.15, 7.04±1.02, 6.62±1.80, 5.64±1.08, 4.59±1.15. Septal E / E ′ were 11.57±2.72, 12.77±2.53, 13.81±3.05, 15.25±2.42, 17.34±7.46 and lateral E / E ′ were 8.32±1.72, 10.68±2.34, 13.48±4.91, 15.49±2.55, 15.43±6.21. Mean values for septal and lateral E / E ′, subdivided according to gender are shown in Fig. 1 . Median septal E ′ was less than lateral E ′, 5.25 (IQR 1.8) vs. 6.60 (IQR 1.3), P <0.001. Consequently, median septal E / E ′ was higher than median lateral E / E ′, 12.89 (IQR 4.0) vs. 11.64 (IQR 5.8), P =0.008. Both septal and lateral E ′ significantly correlated with age, R =−0.713, P <0.001 and R =−0.744, P <0.001; E / E ′ also correlated with age, R =0.436, P <0.001 and R =0.569, P <0.001, respectively.

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British Society of Echocardiography Supplement 2007
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