Extract

277 Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitive cardiac troponins

M Rubini Gimenez, R Hoeller, R Twerenbold, S Sou, M Mueller, R Ziller, K Murray, T Reichlin, T Mosimann, C Mueller

University Hospital Basel, Department of Cardiology, Basel, Switzerland

Purpose

The aim of this study was to examine whether undetectable levels of high-sensitive cardiac Troponin T (hs-cTnT) and I (hs-cTnI) can be used as a single variable to rule out the diagnosis of acute myocardial infarction (AMI) at presentation to the emergency department (ED).

Methods

In an ongoing prospective, international, multicenter study we measured hs-cTnT (Roche) and hs-cTnI using two different precommercial prototype assays (Siemens and Beckmann & Coulter) in consecutive patients presenting to the ED with acute chest pain. The final diagnoses of AMI were adjudicated by two independent cardiologists using all available data including hs-cTnT levels. Patients were followed during a mean period of 23 months.

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