Extract

Acute coronary syndromes: STEMI

110 Prognostic value of circulatory markers of biomechanical stress in patients after q-wave myocardial infarction

A Berezin, T Samura

State Medical University, Zaporozhye, Ukraine

Background

Following acute myocardial infarction (MI), myocytes and the interstitium are changed immediately. Extracellular matrix reposition after MI is considered as a one of powerful integral mechanisms of cardiac remodeling that determinates individual cardiovascular risk value. Matrix metalloproteinases (MMPs) play an important and pivotal role in processes around heart architectonic disorders in subjects after acute MI.

The objective of this study was to compare of prognostic value of ММP-3, ММP-9 and NT-pro-BNP for fatal and non-fatal complications in Q-wave myocardial infarction patients in acute MI and post-MI periods.

Materials and methods

85 patients (male and female) with documented Q-wave myocardial infarction (MI) were observed during 1 year after hospitalization period. Including criteria are: acute Q-wave MI defined by development of acute new Q-wave electrocardiographic changes associated with increased levels of creatine kinase MB fraction >50 IU/L (normal reference 0 to 25 IU/L) or troponin T level >0.1 ng/dL, or new onset left branch bundle block within 72 hours; age older than 18 years; sinus rhythm; written informed consent for participation to the study. Clinical endpoints were identified through the hospital patient tracking system, with review of medical records for each recorded endpoint. LV ejection fraction (LVEF) and wall motion index (WMI) were calculated accordingly conventional methods. Measurements of ММP-3, ММP-9, and NT-pro-BNP concentrations were performed by ELISA.

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