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Overview Overview
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Neurobiological Background of NSSI Neurobiological Background of NSSI
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Psychotherapeutic Interventions as First Treatment of Choice Psychotherapeutic Interventions as First Treatment of Choice
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Psychopharmacological Interventions Psychopharmacological Interventions
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NonPharmaceutical “Biological” Interventions NonPharmaceutical “Biological” Interventions
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Sleep and Physical Activity Sleep and Physical Activity
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Vagal Stimulation Vagal Stimulation
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Repetitive Transcranial Magnetic Stimulation Repetitive Transcranial Magnetic Stimulation
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Transcranial Direct Current Stimulation Transcranial Direct Current Stimulation
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Conclusions Conclusions
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References References
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53 Medical and Pharmaceutical Interventions in NSSI
Get accessPaul L. Plener, Head of the Department of Child and Adolescent Psychiatry, Medical University Vienna
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Published:23 October 2023
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Abstract
There is growing evidence for the efficacy of psychotherapeutic interventions to target nonsuicidal self-injury (NSSI), yet fewer studies have investigated psychopharmacological treatment of NSSI. Although several agents such as selective serotonin reuptake inhibitors (SSRIs), antipsychotics, mood stabilizers, and benzodiazepines have been tested, the evidence for pharmaceutical interventions remains limited. This is especially true for the treatment of minors. There is a general lack of randomized controlled trials in this field of research, with the limited evidence often building on case series and open trials. To date, there is not a licensed psychopharmacological treatment for NSSI. With regard to other “biologically oriented” treatment methods, different modes of stimulation have been tested in populations showing NSSI. These methods include transcranial repetitive magnetic stimulation, transcranial direct current stimulation, and transauricular vagal nerve stimulation. However, evidence for these methods is scarce and reports are mostly based on open label trials. In summary, psychotherapeutic interventions remain the primary method of intervention in NSSI, which can be supported by psychopharmacological interventions to treat comorbid conditions (e.g., depression). There is to date not enough evidence to support specific treatment of NSSI using primarily biologically oriented therapeutic approaches.
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