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Dania Chanab, Mathilde Boucard-Jourdin, Helena Paidassi, Gut Inflammation in Mice Leads to Reduction in αvβ8 Integrin Expression on CD103+CD11b- Dendritic Cells, Journal of Crohn's and Colitis, Volume 11, Issue 2, February 2017, Pages 258–259, https://doi.org/10.1093/ecco-jcc/jjw140
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We have read with great interest the study by Boschetti and colleagues.1 The authors demonstrate that in the context of dextran sodium sulphate [DSS]–induced acute experimental colitis, neoconversion of naïve T cells into induced regulatory T cells [iTregs] in mesenteric lymph nodes [MLNs] is impaired. In addition, they observe that MLN dendritic cells [DCs] from colitic mice have a reduced ability to promote induction of Tregs in vitro as compared with DCs from control mice.1
The generation of iTreg is dependent on transforming growth factor [TGF]–β, which must be activated by αvβ8 integrin on DCs for the in vivo generation of intestinal iTregs and maintenance of immune homeostasis.2–4 MLN CD103-expressing DCs play a critical role in this process, and DSS-induced colitis is associated with a decreased proportion of CD103+ DCs [Figure 1A], as shown by Boschetti et al.1 They thus propose that during colitis, MLN DCs are less efficient at generating Tregs due to the specific loss of CD103+ DCs.
