Volume 58, Issue 1, 1 January 2012

Introduction

Impact of Biomarkers, Proteomics, and Genomics in Cardiovascular Disease

Fred S Apple and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 1–2, https://doi.org/10.1373/clinchem.2011.175919

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Editorials

Growth Differentiation Factor 15: A Canary in a Coal Mine?

Jennifer E Ho and Thomas J Wang

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 3–5, https://doi.org/10.1373/clinchem.2011.175406

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Statins, Plasma Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations, and LDL Lowering

Amit Khera

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 6–7, https://doi.org/10.1373/clinchem.2011.176800

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Delta Cardiac Troponin Values in Practice: Are We Ready to Move Absolutely Forward to Clinical Routine?

Fred S Apple and David A Morrow

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 8–10, https://doi.org/10.1373/clinchem.2011.175414

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Interview

An Interview with Dr. Eugene Braunwald

Misia Landau

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 11–20, https://doi.org/10.1373/clinchem.2011.165845

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Reflection

Reflections on the Evolution of Cardiac Biomarkers

Jack H Ladenson

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 21–24, https://doi.org/10.1373/clinchem.2011.165852

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Perspectives

A Novel Technology for Measuring Cumulative Cardiac Biomarker Exposure over Time: What Happened When We Weren't Looking?

Christopher deFilippi

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 25–27, https://doi.org/10.1373/clinchem.2011.175158

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Within Sight of a Rational Pipeline for Development of Protein Diagnostics

Leigh Anderson

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 28–30, https://doi.org/10.1373/clinchem.2011.173377

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Q&A

The Challenges and Concerns Companies Face Pertaining to the US Food and Drug Administration 510(k) Process for Cardiac Biomarkers

Fred S Apple and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 31–38, https://doi.org/10.1373/clinchem.2011.165860

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Clinical Case Study

Interpreting Changes in Troponin—Clinical Judgment Is Essential

Hugo A Katus and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 39–43, https://doi.org/10.1373/clinchem.2011.173138

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Commentaries

Commentary

Scott W Sharkey

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 43–44, https://doi.org/10.1373/clinchem.2011.176289

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Commentary

Jordi Ordonez-Llanos

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Page 44, https://doi.org/10.1373/clinchem.2011.176297

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Mini-Reviews

Biomarkers in Cardiovascular Clinical Trials: Past, Present, Future

Sharif A Halim and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 45–53, https://doi.org/10.1373/clinchem.2011.165787

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Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

Fred S Apple and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 54–61, https://doi.org/10.1373/clinchem.2011.165795

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Reviews

Use of Natriuretic Peptides to Guide and Monitor Heart Failure Therapy

A Mark Richards and Richard W Troughton

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 62–71, https://doi.org/10.1373/clinchem.2011.165704

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Biomarkers and Cardiovascular Risk Assessment for Primary Prevention: An Update

Lauren G Gilstrap and Thomas J Wang

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 72–82, https://doi.org/10.1373/clinchem.2011.165712

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B-Type Natriuretic Peptide: From Posttranslational Processing to Clinical Measurement

Jens P Goetze

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 83–91, https://doi.org/10.1373/clinchem.2011.165696

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Genomewide Association Studies in Cardiovascular Disease—An Update 2011

Tanja Zeller and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 92–103, https://doi.org/10.1373/clinchem.2011.170431

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9p21 and the Genetic Revolution for Coronary Artery Disease

Robert Roberts and Alexandre F R Stewart

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 104–112, https://doi.org/10.1373/clinchem.2011.172759

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Next Steps in Cardiovascular Disease Genomic Research—Sequencing, Epigenetics, and Transcriptomics

Renate B Schnabel and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 113–126, https://doi.org/10.1373/clinchem.2011.170423

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Emerging Biomarkers in Heart Failure

Roland R J van Kimmenade and James L Januzzi

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 127–138, https://doi.org/10.1373/clinchem.2011.165720

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Metabolomics and Cardiovascular Biomarker Discovery

Eugene P Rhee and Robert E Gerszten

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 139–147, https://doi.org/10.1373/clinchem.2011.169573

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Opinions

Troponin Release—Reversible or Irreversible Injury? Should We Care?

Allan S Jaffe and Alan H B Wu

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 148–150, https://doi.org/10.1373/clinchem.2011.173070

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Are There Really Biomarkers of Vulnerable Plaque?

Bertil Lindahl

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 151–153, https://doi.org/10.1373/clinchem.2011.165811

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Clopidogrel and CYP2C19 Testing: Ready for Clinical Prime Time?

Jean-Sébastien Hulot and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 154–157, https://doi.org/10.1373/clinchem.2011.165829

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Point/Counterpoint

Point: Detection of Myocardial Infarction—Is It All Troponin?

Evangelos Giannitsis and Hugo A Katus

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 158–161, https://doi.org/10.1373/clinchem.2011.168575

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Counterpoint: Detection of Myocardial Infarction—Is It All Troponin? Role of New Markers

Christian Mueller

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 162–164, https://doi.org/10.1373/clinchem.2011.168583

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Point: Put Simply, Standardization of Cardiac Troponin I Is Complicated

Robert H Christenson and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 165–168, https://doi.org/10.1373/clinchem.2011.166140

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Counterpoint: Standardization of Cardiac Troponin I Assays Will Not Occur in My Lifetime

Fred S Apple

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 169–171, https://doi.org/10.1373/clinchem.2011.166165

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Articles

Lipids, Lipoproteins, and Cardiovascular Risk Factors

Association of Growth Differentiation Factor-15 with Coronary Atherosclerosis and Mortality in a Young, Multiethnic Population: Observations from the Dallas Heart Study

Anand Rohatgi and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 172–182, https://doi.org/10.1373/clinchem.2011.171926

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Rosuvastatin, Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations, and LDL Cholesterol Response: the JUPITER Trial

Zuhier Awan and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 183–189, https://doi.org/10.1373/clinchem.2011.172932

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Cystatin C and Estimated Glomerular Filtration Rate as Predictors for Adverse Outcome in Patients with ST-Elevation and Non–ST-Elevation Acute Coronary Syndromes: Results from the Platelet Inhibition and Patient Outcomes Study

Axel Åkerblom and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 190–199, https://doi.org/10.1373/clinchem.2011.171520

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Circulating Troponin As Measured by a Sensitive Assay for Cardiovascular Risk Assessment in Primary Prevention

David M Leistner and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 200–208, https://doi.org/10.1373/clinchem.2011.174292

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Proteomics and Protein Markers

Absolute and Relative Kinetic Changes of High-Sensitivity Cardiac Troponin T in Acute Coronary Syndrome and in Patients with Increased Troponin in the Absence of Acute Coronary Syndrome

Matthias Mueller and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 209–218, https://doi.org/10.1373/clinchem.2011.171827

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Influence of Population Selection on the 99th Percentile Reference Value for Cardiac Troponin Assays

Paul O Collinson and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 219–225, https://doi.org/10.1373/clinchem.2011.171082

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Midregional Proadrenomedullin for Prediction of Cardiovascular Events in Coronary Artery Disease: Results from the AtheroGene Study

Philipp S Wild and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 226–236, https://doi.org/10.1373/clinchem.2010.157842

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Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke

Christian Foerch and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 237–245, https://doi.org/10.1373/clinchem.2011.172676

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Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction

Nora Schaub and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 246–256, https://doi.org/10.1373/clinchem.2011.172940

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Role of ST2 in Non–ST-Elevation Acute Coronary Syndrome in the MERLIN-TIMI 36 Trial

Payal Kohli and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 257–266, https://doi.org/10.1373/clinchem.2011.173369

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Galectin-3 and the Development of Heart Failure after Acute Coronary Syndrome: Pilot Experience from PROVE IT-TIMI 22

E Wilson Grandin and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 267–273, https://doi.org/10.1373/clinchem.2011.174359

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Concordance, Variance, and Outliers in 4 Contemporary Cardiac Troponin Assays: Implications for Harmonization

Jacobus P J Ungerer and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 274–283, https://doi.org/10.1373/clinchem.2011.175059

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Troponin T Measurements by High-Sensitivity vs Conventional Assays for Risk Stratification in Acute Dyspnea

Sandra van Wijk and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 284–292, https://doi.org/10.1373/clinchem.2011.175976

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Brief Communications

Comparison of Midregional Pro–A-Type Natriuretic Peptide and the N-Terminal Pro–B-Type Natriuretic Peptide for Predicting Mortality and Cardiovascular Events

Kornelis J J van Hateren and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 293–297, https://doi.org/10.1373/clinchem.2011.166348

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Biomarkers for Predicting Serious Cardiac Outcomes at 72 Hours in Patients Presenting Early after Chest Pain Onset with Symptoms of Acute Coronary Syndromes

Peter A Kavsak and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 298–302, https://doi.org/10.1373/clinchem.2011.172064

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Citation Classic

Aspirin in the Primary Prevention of Myocardial Infarction

Charles H Hennekens

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 303–304, https://doi.org/10.1373/clinchem.2011.164897

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Letters to the Editor

Evidence-Based Laboratory Medicine: How Well Do Laboratories Follow Recommendations and Guidelines? The Cardiac Marker Guideline Uptake in Europe (CARMAGUE) Study

Paul O Collinson and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 305–306, https://doi.org/10.1373/clinchem.2011.171439

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Copeptin Adds to High-Sensitivity Troponin T in Rapid Rule Out of Acute Myocardial Infarction

Martin Möckel

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 306–307, https://doi.org/10.1373/clinchem.2011.171058

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Copeptin—A Novel Marker in Acute Myocardial Infarction

Stephan von Haehling and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 307–309, https://doi.org/10.1373/clinchem.2011.173658

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In Reply

Mahir Karakas and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 309–311, https://doi.org/10.1373/clinchem.2011.175422

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High-Sensitivity Cardiac Troponin Assays—Change Is Important

Peter A Kavsak and Allan S Jaffe

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 311–313, https://doi.org/10.1373/clinchem.2011.174755

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In Reply

Sally J Aldous and others

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 313–314, https://doi.org/10.1373/clinchem.2011.176305

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Clinical Chemist

Unveiling the Right Side

A Heart-to-Heart Talk

Usha Anand

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 315–316, https://doi.org/10.1373/clinchem.2011.168609

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Science in the Arts

William Harvey and the Undercurrents of Science

Marek H Dominiczak

Clinical Chemistry, Volume 58, Issue 1, 1 January 2012, Pages 317–318, https://doi.org/10.1373/clinchem.2011.177600

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