Volume 55, Issue 4, 1 April 2009

Introduction

Molecular Diagnostics: At the Cutting Edge of Translational Research

Y M Dennis Lo and Carl T Wittwer

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Page 601, https://doi.org/10.1373/clinchem.2008.119586

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Editorials

From Transrenal DNA to Stem Cell Differentiation: An Unexpected Twist

Samuil R Umansky

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 602–604, https://doi.org/10.1373/clinchem.2008.119552

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On Targeting Cell-Free DNA in Urine: A Protocol for Optimized DNA Analysis

Margit Bauer and Barbara Pertl

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 605–606, https://doi.org/10.1373/clinchem.2008.121855

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Next-Generation Sequencing of Plasma/Serum DNA: An Emerging Research and Molecular Diagnostic Tool

Y M Dennis Lo and Rossa W K Chiu

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 607–608, https://doi.org/10.1373/clinchem.2009.123661

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Perspective

A New Tool for Oligonulceotide Import into Cells

Daniel C Leslie and James P Landers

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 609–610, https://doi.org/10.1373/clinchem.2008.113019

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Special Report

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

Stephen A Bustin and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 611–622, https://doi.org/10.1373/clinchem.2008.112797

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Mini-Reviews

MicroRNAs: Novel Biomarkers for Human Cancer

Claudine L Bartels and Gregory J Tsongalis

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 623–631, https://doi.org/10.1373/clinchem.2008.112805

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PCR-Based Methods for the Enrichment of Minority Alleles and Mutations

Coren A Milbury and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 632–640, https://doi.org/10.1373/clinchem.2008.113035

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Reviews

Next-Generation Sequencing: From Basic Research to Diagnostics

Karl V Voelkerding and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 641–658, https://doi.org/10.1373/clinchem.2008.112789

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Microarray-Based Genomic DNA Profiling Technologies in Clinical Molecular Diagnostics

Yiping Shen and Bai-Lin Wu

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 659–669, https://doi.org/10.1373/clinchem.2008.112821

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Analytical Ancestry: “Firsts” in Fluorescent Labeling of Nucleosides, Nucleotides, and Nucleic Acids

Larry J Kricka and Paolo Fortina

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 670–683, https://doi.org/10.1373/clinchem.2008.116152

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Utilizing the Molecular Gateway: The Path to Personalized Cancer Management

Jonathan B Overdevest and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 684–697, https://doi.org/10.1373/clinchem.2008.118554

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Management of Gene Promoter Mutations in Molecular Diagnostics

Karen M K de Vooght and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 698–708, https://doi.org/10.1373/clinchem.2008.120931

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Point/Counterpoint

Point: Use of Pharmacogenetics in Guiding Treatment with Warfarin

Mia Wadelius

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 709–711, https://doi.org/10.1373/clinchem.2008.115964

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Counterpoint: Pharmacogenetic-Based Initial Dosing of Warfarin: Not Ready for Prime Time

Charles S Eby

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 712–714, https://doi.org/10.1373/clinchem.2008.115972

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Molecular Diagnostics and Genetics

Presence of Donor-Derived DNA and Cells in the Urine of Sex-Mismatched Hematopoietic Stem Cell Transplant Recipients: Implication for the Transrenal Hypothesis

Emily C W Hung and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 715–722, https://doi.org/10.1373/clinchem.2008.113530

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Optimization of Transrenal DNA Analysis: Detection of Fetal DNA in Maternal Urine

Eugene M Shekhtman and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 723–729, https://doi.org/10.1373/clinchem.2008.113050

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Profile of the Circulating DNA in Apparently Healthy Individuals

Julia Beck and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 730–738, https://doi.org/10.1373/clinchem.2008.113597

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European External Quality Control Study on the Competence of Laboratories to Recognize Rare Sequence Variants Resulting in Unusual Genotyping Results

János Márki-Zay and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 739–747, https://doi.org/10.1373/clinchem.2008.112102

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Coamplification at Lower Denaturation Temperature-PCR Increases Mutation-Detection Selectivity of TaqMan-Based Real-Time PCR

Jin Li and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 748–756, https://doi.org/10.1373/clinchem.2008.113381

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mRNA Expression and BRAF Mutation in Circulating Melanoma Cells Isolated from Peripheral Blood with High Molecular Weight Melanoma-Associated Antigen-Specific Monoclonal Antibody Beads

Minoru Kitago and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 757–764, https://doi.org/10.1373/clinchem.2008.116467

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Circulating Prostate Tumor Cells Detected by Reverse Transcription-PCR in Men with Localized or Castration-Refractory Prostate Cancer: Concordance with CellSearch Assay and Association with Bone Metastases and with Survival

Pauliina Helo and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 765–773, https://doi.org/10.1373/clinchem.2008.117952

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Interindividual and Interethnic Variation in Genomewide Gene Expression: Insights into the Biological Variation of Gene Expression and Clinical Implications

Harris P Y Fan and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 774–785, https://doi.org/10.1373/clinchem.2008.119107

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Overinterpretation of Clinical Applicability in Molecular Diagnostic Research

Blanca Lumbreras and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 786–794, https://doi.org/10.1373/clinchem.2008.121517

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Evidence-based Medicine and Test Utilization

Familial and Sporadic Porphyria Cutanea Tarda: Characterization and Diagnostic Strategies

Aasne K Aarsand and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 795–803, https://doi.org/10.1373/clinchem.2008.117432

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Point-of-Care Testing

Rapid Single-Nucleotide Polymorphism Detection of Cytochrome P450 (CYP2C9) and Vitamin K Epoxide Reductase (VKORC1) Genes for the Warfarin Dose Adjustment by the SMart-Amplification Process Version 2

Tohru Aomori and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 804–812, https://doi.org/10.1373/clinchem.2008.115295

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Infectious Disease

Generating Aptamers for Recognition of Virus-Infected Cells

Zhiwen Tang and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 813–822, https://doi.org/10.1373/clinchem.2008.113514

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Brief Communication

A Multiplex Assay for Detecting Genetic Variations in CYP2C9, VKORC1, and GGCX Involved in Warfarin Metabolism

Alex J Rai and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 823–826, https://doi.org/10.1373/clinchem.2008.118497

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Clinical Case Study

Genetic Testing for Developmental Delay: Keep Searching for an Answer

David T Miller and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 827–830, https://doi.org/10.1373/clinchem.2008.119438

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Commentary

Sau Wai Cheung

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 830–831, https://doi.org/10.1373/clinchem.2008.122713

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Commentary

Nelson L S Tang

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 831–832, https://doi.org/10.1373/clinchem.2008.122739

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Citation Classics

The Beginnings of Real-Time PCR

P Mickey Williams

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 833–834, https://doi.org/10.1373/clinchem.2008.122226

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Interview

A Conversation with Elizabeth Blackburn

Misia Landau

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 835–841, https://doi.org/10.1373/clinchem.2008.119578

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Letter to the Editor

Validity of Maternal Genotypes in DNA from Archival Pregnancy Serum Samples

Malin I L Ivarsson and others

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Pages 842–843, https://doi.org/10.1373/clinchem.2008.116277

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Clinical Chemist

Lily Robinson and the Mount Vernon Affair: Recollections

Clinical Chemistry, Volume 55, Issue 4, 1 April 2009, Page 844, https://doi.org/10.1373/clinchem.2008.124701

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