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Kimberly G Blumenthal, Bohang Jiang, Andrew J King, Jushin T Mann, Yuqing Zhang, Alysse G Wurcel, Derivation and Validation of an Electronic Health Record Penicillin Allergy De-Labeling Prevalence Measure, Clinical Infectious Diseases, Volume 80, Issue 4, 15 April 2025, Pages 723–726, https://doi.org/10.1093/cid/ciae641
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Abstract
With no standard method to capture penicillin allergy de-labeling prevalence across populations, we developed and validated a simple penicillin allergy de-labeling prevalence measure from electronic health records that achieved perfect sensitivity (100.0%), high specificity (99.4%), and strong agreement with a comprehensive algorithm that included free-text manual review (kappa = .997).

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