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Rachel K Russ, Haley M Vandehei, Maria I Golovkina, Harshitha Mogallapalli, Freddy Caldera, Mary S Hayney, Hepatitis B–CpG Vaccine Series for Healthcare Workers Who Are Hepatitis B Vaccine Nonresponders, Clinical Infectious Diseases, Volume 79, Issue 2, 15 August 2024, Pages 562–563, https://doi.org/10.1093/cid/ciae320
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Abstract
This prospective study enrolled healthcare workers (HCWs) who were nonresponders following at least 5 doses of aluminum-adjuvanted hepatitis B vaccine who received the 2-dose Heplisav-B (HepB-CpG) (Dynavax Technologies Corporation, Emeryville, CA) series. After 2 doses of HepB-CpG, 43/47 (91%) participants, and with 1 dose, 41/49 (84%) responded. HepB-CpG could be the preferred vaccine in HCW nonresponders.
Clinical Trials Registration.Clinicaltrials.gov NCT04456504.