Whitley RJ et al (Clin Infect Dis 2013; 56:1197–205) Free

An error appeared in the 1 May 2013 issue of the journal [Whitley RJ, Boucher CA, Lina B, et al. Global Assessment of Resistance to Neuraminidase Inhibitors, 2008–2011: The Influenza Resistance Information Study (IRIS). Clin Infect Dis 2013; 56:1197–205]. A naturally oseltamivir-resistant H1N1pdm2009 virus carrying a D199N mutation in neuraminidase was reported to have an oseltamivir IC₅₀ of 7.2nM. However, the oseltamivir IC₅₀ of reverse genetically-engineered viruses carrying the neuraminidase of this virus was found to be 1.2 ± 0.2 nM, and a recultured virus from the original patient sample also had an oseltamivir IC₅₀ of 1.2 ± 0.2 nM. These data are in line with previously published data reporting a 3- to 4-fold increase in oseltamivir IC₅₀ resulting from the D199N mutation in an N1 background (Deyde et al. Antimicrob Agents Chemother 2010; 54:1102–10).

The authors regret this error.