-
Views
-
Cite
Cite
Hsien-Yi Chiu, Chia-Ying Chang, Po-Ren Hsueh, Tsen-Fang Tsai, I-Lin Liu, Li-Fang Wang, Multiple Discrete, Punched-out Ulcers in a Patient With Pemphigus Vulgaris, Clinical Infectious Diseases, Volume 53, Issue 4, 15 August 2011, Pages 396–398, https://doi.org/10.1093/cid/cir351
Close - Share Icon Share
Extract
(See pages 377–378 the Photo Quiz.)
Diagnosis: Primary Cutaneous Mucormycosis Caused by Absidia Corymbifera
Sections of the biopsy specimen obtained from ulcerative lesions on the patient’s chest (Figure 1) showed suprabasal or intraepithelial acantholysis. Scattered broad, branching, pauciseptate hyphae in necrotic debris with neutrophilic infiltration, giant cells and granuloma formation in the dermis and papillary dermis were also noted (Figure 2). Additionally, cultures of wound secretion were also positive for Absidia corymbifera (Figure 3). We also use oligonucleotide array designed on the basis of the internal transcribed spacer regions to confirm the identification of Absidia corymbifera [1]. No virus or mycobacteria were isolated from the swabs taken from the lesions. Laboratory tests and image findings were otherwise unremarkable.
The patient was treated with itraconazole 200mg twice daily and the dose of prednisolone was also decreased to 60mg daily two days before the initiation of itraconazole therapy. These ulcerative lesions healed several weeks after itraconazole therapy with depressed scars.
