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Andrew Prendergast, A. Sarah Walker, Veronica Mulenga, Chifumbe Chintu, Diana M. Gibb, Improved Growth and Anemia in HIV-Infected African Children Taking Cotrimoxazole Prophylaxis, Clinical Infectious Diseases, Volume 52, Issue 7, 1 April 2011, Pages 953–956, https://doi.org/10.1093/cid/cir029
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Abstract
The impact of cotrimoxazole (CTX) on growth and/or anemia was investigated in 541 human immunodeficiency virus-infected, antiretroviral therapy–naive Zambian children enrolled in the Children with HIV Antibiotic Prophylaxis trial. Compared with children randomized to receive placebo, children randomized to receive CTX had slower decreases in weight-for-age (P = .04) and height-for-age (P = .01), and greater increase in hemoglobin level (P = .01). These findings argue for expanded early CTX use.