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Yolanda Meije, Manuel Lizasoain, Ana García Reyne, Pilar Martínez, Virginia Rodríguez, Francisco López-Medrano, Rafael San Juan, Antonio Lalueza, José María Aguado, Emergence of Cytomegalovirus Disease in Patients Receiving Temozolomide: Report of Two Cases and Literature Review, Clinical Infectious Diseases, Volume 50, Issue 12, 15 June 2010, Pages e73–e76, https://doi.org/10.1086/653011
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Abstract
Temozolomide chemotherapy has become part of the therapy used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Temozolomide frequently produces profound lymphopenia. We report 2 cases of cytomegalovirus disease that occurred in patients receiving temozolomide therapy and review 4 additional cases reported in the literature. Narrow monitoring with cytomegalovirus antigenemia assay should be considered for recommendation.