-
Views
-
Cite
Cite
Jay P. Sanford, Session II: Summary, Reviews of Infectious Diseases, Volume 5, Issue Supplement_3, July-August 1983, Pages S515–S522, https://doi.org/10.1093/clinids/5.Supplement_3.S523
- Share Icon Share
Abstract
In a prospective, randomized study of staphylococcal infections, 27 patients received oxacillin plus rifampin and 29 received oxacillin alone. Vancomycin was substituted for oxacillin when the pathogen was demonstrated to be resistant to oxacillin in vitro. Infection was cured in 18 (67%) of the 27 patients receiving oxacillin (or vancomycin) plus rifampin and in 12 (41%) of the 29 receiving oxacillin (or vancomycin) alone (P <.01). The clinical effect of the addition of rifampin to oxacillin (or vancomycin) was beneficial in spite of a rifampin-associated reduction in the bactericidal activity of serum containing high concentrations of oxacillin.