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Markus Braun-Falco, Heidelore Hofmann, An HIV-Positive Man with Slowly Enlarging Nodules on the Extremities, Clinical Infectious Diseases, Volume 44, Issue 7, 1 April 2007, Pages 1009–1010, https://doi.org/10.1086/512373
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Diagnosis: Nodular erythema elevatum diutinum (nEED).
The development of disseminated, dark, purpuric skin nodules in HIV-infected patients is usually suspicious for Kaposi sarcoma or bacillary angiomatosis [1, 2]. In the present case, a diagnosis of nEED was made on the basis of the clinical presentation and histological findings characteristic for nEED—namely, a nodular accumulation of histiocytes, spindle cells, and neutrophils displaying areas of heavy neutrophilic infiltration with fibrinoid necrosis and nuclear dust adjacent to areas with marked tissue fibrosis (figure 1)—in conjunction with the failure to detect any infectious agents, such as human herpesvirus 8 or Bartonella henselae.
nEED is an extremely rare cause of HIV-associated skin nodules and can, therefore, be easily missed in the differential diagnosis [3]. To the best of our knowledge, ∼20 cases of nEED in association with HIV infection have been published [3–9]. Erythema elevatum diutinum is a rare, chronic vasculitis of unknown etiology that promotes tissue fibrosis. The nodular variant is even rarer, but it evolves most often in HIV-positive individuals [10]. Although the pathophysiology of erythema elevatum diutinum is unclear, it has been reported several times in association with IgA hypergammopathy [11], which is also a common finding in HIV infection. One may speculate that the hemorrhagic macules were initially caused by an IgA-associated vasculitis. Because of the induced leakage of the vessel walls, lipid droplets (which were markedly elevated in the serum after ritonavir intake) poured into the perivascular tissue and became phagocytosed by histiocytes. The ongoing inflammation finally induced fibrotic tissue remodeling.
